Mac OS Big Sur
When you download EndNote 20, you'll need to immediately run "Check for updates" from the EndNote 20 menu and update to 20.1. Once you update, you should not have any issues with Big Sur.
Mac OS Catalina
If you have the Catalina operating system, you MUST use EndNote version X9.3 or higher. Catalina is a 64-bit system, and all older versions of EndNote are 32-bit.
Mac OS prior to Catalina
M1 Chip Macs
The new M1 chips are by Apple, not AMD Intel. Some third-party programs automatically run the chip as Intel, others require a setting change. Rosetta is what usually allows the chip to run. This will likely not cause a problem with downloading or using EndNote, but it may cause a problem using EndNote with Word. Please see the Word for Mac section for instructions and screenshots for enabling Rosetta.
1) Check for compatibility. New system problems or updates are listed in the box above.
2) Quit your word processing program AND the whole Office suite. In other words, quit Outlook, Excel, PowerPoint, etc. Closing the window (clicking the red button) is not enough. Make sure you File>Quit.
3) Download the Firefox web browser. UGA Libraries still recommends that you use Firefox as your EndNote export browser instead of Safari. Most users having issues exporting database references use Safari. You can certainly have several browsers, and use something else for personal browsing or other projects.
The first time you send database references to EndNote, designate the program to open files.