ebook The emergence of H5N1 avian influenza in 1997 and of the influenza A H1N1 of swine origin in 2009 calls for new, rapid and sustainable solutions for both seasonal and pandemic influenza viruses. During the last ten years, science and technology have made enormous progress, and we are now able to monitor in real time the genetics of viruses while they spread globally, to make more powerful vaccines using novel adjuvants, and to generate viruses in the laboratory using reverse genetics. This volume not only provides state-of-the-art information on the biology of influenza viruses and on influenza vaccines, but is also designed to be a resource to face the present H1N1 pandemic and to plan for long-term global and sustainable solutions.
ebook Infectious disease pandemics are a rising threat in our globalizing world. This agenda-setting collection provides international analysis of the pressing sociological concerns they confront us with, from cross-border coordination of public health governance to geopolitical issues of development and social equity. Focuses on vital sociological issues raised by resurgent disease pandemics Detailed analysis of case studies as well as broader, systemic factors Contributions from North America, Europe and Asia provide international perspective Bold, agenda-setting treatment of a high-profile topic
ebook Infectious agents remain a substantial threat to the operational capacity of U.S. military forces. In Protecting Our Forces: Improving Vaccine Acquisition and Availability in the U.S. Military, the Institute of Medicine convened a committee to review the process by which the U.S. military acquires vaccines to protect its war fighters against natural infectious disease threats.
Science Library 4th floor, RA638 .C38 2017 Few topics in health policy have generated as much debate--and frustration--among public health experts as the issue of vaccine safety. Misinformation around the science of vaccination continues to spread, and too often the media fails to report bad science for what it is. Using science-informed analysis alongside original art and powerful essays, health science leader Timothy Caulfield debunks the myths and false assumptions about vaccination safety and effectiveness. Accessible, informative, and entertaining, The Vaccination Picture tells the true story of vaccines, their uses, and their positive effects for everyone.
ebook "Development of novel vaccines" gives an overview of the tasks in basic research leading to the final product - the vaccine and its applications, belonging to the most complex biologics in the pharmaceutical field. Distinct from most textbooks in the vaccine arena, the current issue focuses on the translational aspect, namely, how research results can be transformed into life-saving medical interventions. Each chapter of the book deals with one important paradigm for the development of novel vaccines, along the value chain towards the final vaccine, and furthermore, with the inevitable tools required for this process. Contributions are prepared by teams of scientists, all of whom are experts in the field, most of them anchored in biomedical organizations devoted to translational culture, thereby lighting the certain topics from different views. This volume is a must read for researchers engaged in vaccine development and who really want to see their research results to become a product.
ebook Vaccine Manufacturing and Production is an invaluable reference on how to produce a vaccine - from beginning to end - addressing all classes of vaccines from a processing, production, and regulatory viewpoint. It will provide comprehensive information on the various fields involved in the production of vaccines, from fermentation, purification, formulation, to regulatory filing and facility designs. In recent years, there have been tremendous advances in all aspects of vaccine manufacturing. Improved technology and growth media have been developed for the production of cell culture with high cell density or fermentation. Vaccine Manufacturing and Production will serve as a reference on all aspects of vaccine production by providing an in-depth description of the available technologies for making different types of vaccines and the current thinking in facility designs and supply issues. This book will provide insight to the issues scientists face when producing a vaccine, the steps that are involved, and will serve as a reference tool regarding state-of-the-art vaccine manufacturing technologies and facility set-up. Highlights include: Comprehensive coverage of vaccine production : from a process point of view- fermentation to purification to formulation developments; from a production point of view - from facility design to manufacturing; and from a regulatory point of view - requirements from government agencies Authors from different major pharmaceutical and biotechnology companies Describes the challenges and issues involved in vaccine production and manufacturing of the different classes of vaccines, an area not covered by other books currently on the market
online report Operation Warp Speed (OWS)—a partnership between the Departments of Health and Human Services (HHS) and Defense (DOD)—aimed to help accelerate the development of a COVID-19 vaccine. GAO found that OWS and vaccine companies adopted several strategies to
accelerate vaccine development and mitigate risk.
ebook "... this book was written from start to finish by one extremely dedicated and erudite individual. The author has done an excellent job of covering the many topics that fall under the umbrella of computational biology for vaccine design, demonstrating an admirable command of subject matter in fields as disparate as object-oriented databases and regulation of T cell response. Simply put, it has just the right breadth and depth, and it reads well. In fact, readability is one of its virtues--making the book enticing and useful, all at once..." Human Vaccines, 2010 "... This book has several strong points. Although there are many textbooks that deal with vaccinology, few attempts have been made to bring together descriptions of vaccines in history, basic bioinformatics, various computational solutions and challenges in vaccinology, detailed experimental methodologies, and cutting-edge technologies... This book may well serve as a first line of reference for all biologists and computer scientists..." -Virology Journal, 2009 Vaccines have probably saved more lives and reduced suffering in a greater number of people than any other medical intervention in human history, succeeding in eradicating smallpox and significantly reducing the mortality and incidence of other diseases. However, with the emergence of diseases such as SARS and the threat of biological warfare, vaccination has once again become a topic of major interest in public health. Vaccinology now has at its disposal an array of post-genomic approaches of great power. None has a more persuasive potential impact than the application of computational informatics to vaccine discovery; the recent expansion in genome data and the parallel increase in cheap computing power have placed the bioinformatics exploration of pathogen genomes centre stage for vaccine researchers. This is the first book to address the area of bioinformatics as applied to rational vaccine design, discussing the ways in which bioinformatics can contribute to improved vaccine development by introducing the subject of harnessing the mathematical and computing power inherent in bioinformatics to the study of vaccinology putting it into a historical and societal context, and exploring the scope of its methods and applications. Bioinformatics for Vaccinology is a one-stop introduction to computational vaccinology. It will be of particular interest to bioinformaticians with an interest in immunology, as well as to immunologists, and other biologists who need to understand how advances in theoretical and computational immunobiology can transform their working practices.
ebook and print Main Library 2nd floor, KF3808 .K57 2016 A behind-the-scenes examination of the special court dedicated to claims that vaccines have caused harm The so-called vaccine court is a small special court in the United States Court of Federal Claims that handles controversial claims that a vaccine has harmed someone. While vaccines in general are extremely safe and effective, some people still suffer severe vaccine reactions and bring their claims to vaccine court. In this court, lawyers, activists, judges, doctors, and scientists come together, sometimes arguing bitterly, trying to figure out whether a vaccine really caused a person's medical problem. In Vaccine Court, Anna Kirkland draws on the trials of the vaccine court to explore how legal institutions resolve complex scientific questions. What are vaccine injuries, and how do we come to recognize them? What does it mean to transform these questions into a legal problem and funnel them through a special national vaccine court, as we do in the US? What does justice require for vaccine injury claims, and how can we deliver it? These are highly contested questions, and the terms in which they have been debated over the last forty years are highly revealing of deeper fissures in our society over motherhood, community, health, harm, and trust in authority. While many scholars argue that it's foolish to let judges and lawyers decide medical claims about vaccines, Kirkland argues that our political and legal response to vaccine injury claims shows how well legal institutions can handle specialized scientific matters. Vaccine Court is an accessible and thorough account of what the vaccine court is, why we have it, and what it does.
Science Library 4th floor, RA643 .S67 2008 Social Ecology of Infectious Diseases explores how human activities enable microbes to disseminate and evolve, thereby creating favorable conditions for the diverse manifestations of communicable diseases. Today, infectious and parasitic diseases cause about one-third of deaths and are the second leading cause of morbidity and mortality. The speed that changes in human behavior can produce epidemics is well illustrated by AIDS, but this is only one of numerous microbial threats whose severity and spread are determined by human behaviors. In this book, forty experts in the fields of infectious diseases, the life sciences and public health explore how demography, geography, migration, travel, environmental change, natural disaster, sexual behavior, drug use, food production and distribution, medical technology, training and preparedness, as well as governance, human conflict and social dislocation influence current and likely future epidemics.
ebook This volume focuses on the contributions that social scientists can make to understanding emerging epidemics, their impact, the threats they pose, and their social and political contexts. While many of the international articles focus on infectious disease, some discussion is given to treating psychiatric epidemics and the analysis of the political and cultural meanings that epidemics have. A sociological volume on emerging epidemics, covering psychiatric or psychological diseases as well as infectious disease is long overdue and topics included here are as wide ranging as: bipolar disorder; obesity; malaria; HIV/AIDS; SARS; West Nile Virus; pandemic influenzas; deviance; depression; ADHD; Alzheimer's; and autism. This valuable reference tool empirically examines emerging epidemics themselves and offers a theoretical analysis of the use of epidemics and epidemiology as frameworks for understanding these phenomena. It will appeal to a broad audience of readers of researchers and practitioners in this field, ranging from those involved in public health policy, human security and community health to medical sociologists and other scientists working in health and medicine.
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